Authors may use MDPI'sĮnglish editing service prior to publication or during author revisions. Submitted papers should be well formatted and use good English. For details about the APC please see here. There is an Article Processing Charge (APC) for publication in this Please visit the Instructions for Authors page before submitting a manuscript. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. All manuscripts are thoroughly refereed through a single-blind peer-review process. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Research articles, review articles as well as short communications are invited. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. All submissions that pass pre-check are peer-reviewed. Manuscripts can be submitted until the deadline. Once you are registered, click here to go to the submission form. Manuscripts should be submitted online at by registering and logging in to this website. This Special Issue of IJMS will cover the peculiar and intricate roles of PGC-1s in the ensemble of processes that are associated with mitochondrial and cellular metabolism in human physiopathology. These transcriptional cofactors are activated in different organs (such as muscle, brain, liver and brown adipose tissue) not only to fulfil high energy demands, but also to control and/or modulate several metabolic pathways, whose alterations have been described in multiple diseases. The members of the peroxisome proliferator-γ activated receptor (PPAR)-γ coactivator 1 (PGC-1) family are key regulators of the generation of new mitochondria. In this view, mitochondrial biogenesis is a crucial step for the maintenance of a healthy mitochondrial network.
Consequently, it is not surprising that mitochondrial dysfunctions are implicated in numerous pathological conditions, ranging from metabolic to neurodegenerative diseases and cancer. Besides their central role in cellular energy metabolism, mitochondria are involved in other physiological processes, such as reactive oygen species (ROS), iron and calcium homeostasis as well as apoptosis. Mitochondria represent the major metabolic hub of the cells.
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